Cost-effectiveness analysis of secukinumab in ankylosing spondylitis from the Canadian perspective

Aim: To assess the cost-effectiveness of interleukin (IL)-17A inhibitor secukinumab vs the currently licensed biologic therapies in ankylosing spondylitis (AS) patients from a Canadian healthcare system perspective.

Methods: A decision analytic model (semi-Markov) evaluated the cost-effectiveness of secukinumab 150?mg compared to certolizumab pegol, adalimumab, golimumab, etanercept and etanercept biosimilar, and infliximab and infliximab biosimilar in a biologic-naïve population, over 60 years of time horizon (lifetime). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI 50) response rate was used to assess treatment response at week 12. Non-responders or patients discontinuing initial-line of biologic therapy were allowed to switch to subsequent-line biologics. Model input parameters (short-term and long-term changes in BASDAI and Bath Ankylosing Spondylitis Functional Index [BASFI], withdrawal rates, adverse events, costs, resource use, utilities, and disutilities) were obtained from clinical trials, published literature, and other Canadian sources. Benefits were expressed as quality-adjusted life years (QALYs). Cost and benefits were discounted with an annual discount rate of 1.5% for all treatments.

Results: In the biologic-naïve population, secukinumab 150?mg dominated all comparators, as patients treated with secukinumab 150?mg achieved the highest QALYs (16.46) at the lowest cost (CAD 533,010) over a lifetime horizon vs comparators. In the deterministic sensitivity analysis, results were most sensitive to changes in baseline BASFI non-responders, BASDAI 50 at 3 months and discount rates. Probabilistic sensitivity analysis showed that secukinumab 150?mg demonstrated higher probability of achieving maximum net monetary benefit vs all comparators at various cost thresholds.

Conclusions: This analysis demonstrates that secukinumab 150?mg is the most cost-effective treatment option for biologic-naïve AS patients compared to certolizumab pegol, adalimumab, golimumab, etanercept and etanercept biosimilar, and infliximab and infliximab biosimilar for a lifetime horizon in Canada. Treatment with secukinumab translates into substantial benefits for patients and the healthcare system.     

企业并购溢价对企业绩效的影响研究——基于我国沪深A股的实证检验

近年来,我国并购市场如火如荼,越来越多的企业选择通过并购来实现自己的战略目标,迅速占据市场地位,进入新兴行业。在并购交易热潮下,高溢价似乎也成为并购重组的"标配",高溢价并购屡见不鲜。可是企业支付高溢价换来的是否为优质资产,其是否能给企业带来价值的提升,这些都是值得研究的议题。因此,文章基于我国并购交易市场,研究了国内上市公司并购溢价的绩效反应。运用相关性分析、多元回归分析等研究方法探讨了并购支付溢价对并购绩效的影响。最后,根据实证研究结果阐述本文的结论,给出相应的建议。研究结果表明:并购溢价在一定程度上代表了并购后协同效应的大小,支付的溢价越高表明预期达成的协同效应越大,企业后期的绩效表现会越好。     

中国企业“逆周期”跨国并购研究

"新常态"经济周期中,中国企业跨国并购有何特征?从经济政策频繁波动的现实出发,如何理解跨国并购的"逆周期"成因?文章基于2001-2016年中国企业对91个国家的跨国并购数据,实证检验了经济周期、经济政策不确定性对跨国并购的影响,得出以下结论：首先,中国企业的跨国并购具有显著的"逆周期"特征,下行经济周期加剧了并购规模提升;其次,经济政策不确定性与跨国并购正相关,并且在国有企业中和2008年金融危机后表现为更明显;最后,经济政策不确定性差距以及市场增长潜力差距均提升了并购规模。     

资产专用性视角下战略性新兴产业并购创新绩效

中国战略性新兴产业并购事件逐年增加,其中以获取技术为目标的并购事件不断涌现。基于2010—2017年战略性新兴产业上市公司数据,对比并购前后专利申请数量发现相比于并购前,并购后企业创新绩效有显著提高且影响具有一定持续性。通过负二项回归检验企业并购经验、并购价格、资产专用性等因素对创新绩效的影响。研究结果显示,企业并购价格对战略性新兴产业上市公司并购创新绩效产生正向促进作用,企业资产专用性在并购价格与创新绩效之间、并购经验与创新绩效之间都具有负向调节作用。研究结论拓展了影响战略性新兴产业创新绩效的研究,为政府制定相关扶持政策、企业并购等方面提供了实证依据和决策参考。     

多元化并购、资源基础与制造企业服务化转型——基于fsQCA的多案例分析

为探究制造业企业通过并购实现服务化的转型路径,以2014至2018年制造企业并购服务企业并购事件为研究对象,运用组态思维和fsQCA方法整合服务型资源质量维度与服务型资源整合维度的5个前因条件,讨论前因变量组合与制造业服务化转型之间的复杂因果机制。结果表明,制造业服务化转型存在3条转型路径,即研发能力驱动型、财务能力驱动型和服务化经验驱动型。通过分析路径和典型案例发现：在评估服务型资源质量时,标的方的盈利能力、研发能力存在替代效应;并购方财务柔性在基于并购的服务化转型中具有重要作用;并购方服务化经验有助于并购整合。     

Ranking U.S. Economics Programs by Faculty and Graduate Publications: An Update Using 1994–2009 Data

This article ranks academic institutions by pages published in top economics journals over the 1994–2001 and 2002–2009 periods. Because it uses a methodology similar to several earlier articles, this article permits a consideration of how institutions' ranks have changed over the past 35 years. I construct rankings based on publications by individuals affiliated with each institution, by faculty members in the economics departments at each institution, and by alumni of each doctoral program. With few exceptions, the positions of programs near the top of the rankings change little over time. However, much more dramatic changes in rank occur for lower‐ranked institutions.     

美中应对金融危机的货币政策及其效果比较

2007年在美国爆发的次贷危机和金融危机对全球经济造成了巨大、强烈而深远的影响和冲击。中美两国各自根据国情及危机产生的根源的不同分别采取了及时积极的货币政策和财政政策,本文从两国货币政策实施的具体操作措施、实施的时间、目标、政策工具和力度、实施效果、经济恢复情况及目前仍存在的经济问题进行了详细的比较和分析。     

纤维转盘滤池在污水处理厂深度处理中的应用

文章结合天津某污水处理厂升级改造工程的实例,介绍了一种先进的新型过滤技术--纤维转盘滤池的使用情况,对纤维转盘滤池的结构、运行状态、特点等均做了详细说明。     

上市公司收购境内企业外资股权的财务绩效研究

以我国上市公司收购海外资本持有内地企业股权的案例为研究对象,采用因子分析法对并购的财务绩效进行分析,结果显示:从样本总体来看,上市公司收购海外资本所持内地企业的股权后财务绩效得到了明显的改善;企业性质、规模和行业类别不同的上市公司样本并购后的财务绩效表现差别很大。     

Marketing research by a small industrial firm: A case study

There is a growing need today for industrial marketers to conduct marketing research and use the results in making profitable business decisions. This paper describes a marketing research study conducted by a small industrial firm and discusses the nature and extent of its impact on the firm's operations. Several implications and practical guidelines are derived for industrial marketers in general, based on the firm's marketing research experience.